The Development of a Myeloablative, Reduced-Toxicity, Conditioning Regimen for Cord Blood Transplantation
نویسندگان
چکیده
منابع مشابه
Unrelated Bone Marrow Transplantation with a Reduced Toxicity Myeloablative Conditioning Regimen in Wiskott-Aldrich Syndrome
Wiskott-Aldrich syndrome (WAS) is an X-linked congenital immune-deficiency syndrome, and bone marrow transplantation (BMT) has become a curative modality. However, the transplant with the alternative donor needed more intensive conditioning with increased treatment-related toxicities. Recently, fludarabine-based reduced toxicity myeloablative conditioning regimens have been developed for adult ...
متن کاملEngraftment kinetics and graft failure after single umbilical cord blood transplantation using a myeloablative conditioning regimen.
Umbilical cord blood transplant recipients are exposed to an increased risk of graft failure, a complication leading to a higher rate of transplant-related mortality. The decision and timing to offer a second transplant after graft failure is challenging. With the aim of addressing this issue, we analyzed engraftment kinetics and outcomes of 1268 patients (73% children) with acute leukemia (64%...
متن کاملUnrelated Donor Hematopoietic Stem Cell Transplantation for Treatment of Non-Malignant Genetic Diseases Using a Myeloablative Reduced Toxicity Conditioning Regimen
s / Biol Blood Marrow Transplant 21 (2015) S206eS239 S239 was 11%. Incidence of chronic GVHD was 20%, severe chronic GVHD was 4%. 5 children died due to transplant related mortality (TRM), all of them were class 3 Thalassemia; 2 patients transplanted from unrelated donor and unrelated cord and 2 died after second HSCT. Causes of deaths were severe infections secondary to engraftment failure; se...
متن کاملTreosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation.
New conditioning regimens are being explored to reduce toxicity and enable allogeneic bone marrow transplantation in patients not eligible for conventional transplantation. We have investigated treosulfan, an alkylating agent, with the aim of developing an efficient and reliable but less-toxic conditioning regimen. A series of 30 patients who were not eligible for standard conditioning therapy ...
متن کاملreduced intensity versus full myeloablative conditioning in allogeneic stem cell transplantation for acute myeloid leukemia
introduction: allogeneic hematopoietic stem cell transplantation (hsct) has been reported to be a successful curative treatment in aml patients. myeloablative conditioning (mac) is used more frequent as a preparing regimen. this study attempts to compare the outcome of patients who has received mac and reduced- intensity conditioning (ric). methods: totally, 618 patients with aml underwent hsct...
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ژورنال
عنوان ژورنال: Clinical Lymphoma Myeloma and Leukemia
سال: 2014
ISSN: 2152-2650
DOI: 10.1016/j.clml.2013.08.006